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Another contraindication is the use of GLP-1RA in patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2 (33, 34, 36)

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June 2025: The European Medicines Agencys (EMAs) safety committee concluded that NAION is a very rare potential side effect of semaglutide medicines, like Wegovy

The authors suggested that this increased peripheral exposure near the Ki of MC1R may have led to the observed increase in pigmentation